Fewer mismatches do not mean a safer blood stem cell transplant.

In the modern transplantation era, fewer donor-recipient HLA mismatches do not automatically mean a safer blood stem cell transplant.

Current donor selection practice still counts HLA mismatches, treating most as equal risk. Clinical data show that certain HLA mismatches are safe, while others trigger GVHD.

Non-HLA factors such as donor/recipient age, gender, and CMV status also matter.

Our software evaluates donor risk by integrating HLA and non-HLA factors simultaneously.

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